Prestige

Diamond Upgrades & Automation and Generator Shop
Diamond upgrades are unlocked upon the first Prestige, and are the second tier of upgrades. I don't remember when automation and generator shops were unlocked, but automation shop lets you automate things, and generator shop is for upgrades that make new tiers of buildings produce previous tiers of buildings.

Diamond Buildings & Crystal Upgrades
Diamond buildings are the second tier of upgrades and produce crystals, which multiply coin production. Crystals can alo be used to buy crystal upgrades, the first one provides "a 5% multiplicative boost to crystals per AP per level", the second one provides "a boost to crystals based on held coins per level", the third provides "Each purchased Crystal producer increases generation of Crystal producers by 0.1% per level. [MAX: 12%]", the fourth provides "Improve the multiplier to coin production by .05 exponent per level. [MAX: +10.00]", and the fifth provides "Every challenge completion increases crystal gain by 1% per level".

Runes
Runes are unlocked upon the first prestige, and cost offerings, which will be gained from every reset tier until ascension. It starts off with just the speed rune, which provides "+(Level/4)^1.25 Accelerator, +0.25% Accelerators per level. +1 Accelerator Boost every 20 levels!", the second rune to be unlocked is the duplication rune, unlocked when prestiging for at least 1e100 diamonds the first time, and provides "+(Level/10) Multipliers every 10th level, +0.25% Multipliers per level. Tax growth is delayed more for each level!", 2 more runes are unlocked in the transcension tier, and 1 more in the reincarnation tier.

Accelerator Boosts
Accelerator boosts are sort of a tier in between the first(prestige) and second(transcension) tiers of reset. It resets "Coin Producers/Upgrades, Crystals and Diamonds in order to increase the power of your accelerators" every accelerator boost requires you to have reached a higher amount of diamonds than the last.