Runes

Throughout the game, you will unlock runes. Runes give you bonuses, and can be leveled up to increase said bonuses by sacrificing offerings. In the late game, a second tier of runes called Blessings is unlocked. Each Blessing has a corresponding rune and gives an effect based on its power, which is the product of its level and the level of its respective rune. Unlike runes, which require EXP to level up, the cost of a Blessing is static and fixed at 1e6(level+1) offerings.

There is also another rune you unlock late game called infinite ascent (IA), which boosts cube and quark gain. Max level: 99 (Quark Gain +35.0%, Ascensions give +125% more of all cube types). Also costs 1e271 rune exp to get there. Towards the endgame, a third tier of runes called Spirits is unlocked.

Spirits can have increased power through using corruptions, unlocked early-game after your first ascension, which increases difficulty through certain nerfs to progress, but also buffs spirits